Often asked: How Does Pernicious Anemia Differ From Nutritional B12 Deficiencyhow Are They Related?

What is the difference between vitamin B12 deficiency and pernicious anemia?

Technically, the term “pernicious anemia” refers to vitamin B12 deficiency due to a lack of intrinsic factor. Often though, vitamin B12 deficiency due to other causes also is called pernicious anemia. This article discusses pernicious anemia due to a lack of intrinsic factor and other causes.

How is B12 related to anemia?

Having vitamin B12 deficiency means that your body does not have enough of this vitamin. You need B12 to make red blood cells, which carry oxygen through your body. Not having enough B12 can lead to anemia, which means your body does not have enough red blood cells to do the job. This can make you feel weak and tired.

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What is the relationship between intrinsic factor and vitamin B12?

Intrinsic factor binds to vitamin B12. After attaching, intrinsic factor and B12 travel to the intestines to be absorbed into the bloodstream. Vitamin B12 is needed for red blood cells to form and grow. Some people do not make enough intrinsic factor or have a condition that destroys it.

What nutrient deficiency causes pernicious anemia?

Pernicious anemia is a type of vitamin B12 anemia. The body needs vitamin B12 to make red blood cells. You get this vitamin from eating foods such as meat, poultry, shellfish, eggs, and dairy products.

What are the neurological symptoms of B12 deficiency?

A lack of vitamin B12 can cause neurological problems, which affect your nervous system, such as:

  • vision problems.
  • memory loss.
  • pins and needles (paraesthesia)
  • loss of physical co-ordination (ataxia), which can affect your whole body and cause difficulty speaking or walking.

Does pernicious anemia shorten your life?

Currently, early recognition and treatment of pernicious anemia provide a normal, and usually uncomplicated, lifespan. Delayed treatment permits progression of the anemia and neurologic complications. If patients are not treated early in the disease, neurological complications can become permanent.

How long does it take to correct a B12 deficiency?

A response usually is seen within 48 to 72 hours, with brisk production of new red blood cells. Once B12 reserves reach normal levels, injections of vitamin B12 will be needed every one to three months to prevent symptoms from returning.

Why is my body not absorbing vitamin B12?

Your body also might not absorb enough vitamin B12 if: You have a disease that affects how nutrients are absorbed in your intestines, such as Crohn’s disease, HIV, or some infections. You have certain bad bacteria in your intestines. You take some medicines, such as antibiotics and anti-seizure drugs.

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Why do I have a B12 deficiency?

Atrophic gastritis, in which your stomach lining has thinned. Pernicious anemia, which makes it hard for your body to absorb vitamin B12. Conditions that affect your small intestine, such as Crohn’s disease, celiac disease, bacterial growth, or a parasite.

How do you know if you lack intrinsic factor?

Most cases result from the lack of the gastric protein known as intrinsic factor, without which vitamin B12 cannot be absorbed. The symptoms of pernicious anemia may include weakness, fatigue, an upset stomach, an abnormally rapid heartbeat (tachycardia), and/or chest pains.

Can you absorb B12 without intrinsic factor?

A small amount of vitamin B12 is absorbed by passive diffusion without intrinsic factor.

Is required for efficient absorption of vitamin B 12?

Two steps are required for the body to absorb vitamin B12 from food. First, hydrochloric acid in the stomach separates vitamin B12 from the protein to which vitamin B12 is attached in food. After this, vitamin B12 combines with a protein made by the stomach called intrinsic factor and is absorbed by the body.

Do B12 tablets work for pernicious anemia?

For long-term maintenance therapy, oral vitamin B12 replacement can be effective in patients with pernicious anemia.

Can you drink alcohol if you have pernicious anemia?

Do not drink alcohol while you are being treated. Alcohol can prevent the body from absorbing vitamin B12. Eat foods that have folate (also called folic acid). This is another type of B vitamin.

What is the correlation between destruction of parietal cells and vitamin B12 deficiency?

The release of vitamin B12 from its dietary protein bound state depends upon an acidic environment in the stomach. The loss of gastric parietal cell mass leads to profound hypochlorhydria and reduced vitamin B12 absorption. Inadequate production of intrinsic factor also leads to vitamin B12 deficiency.

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