FAQ: What Causes High Folate Levels And Low B12?

What does high folate and low B12 mean?

The people with low B12 and high folate levels were more likely to have anemia than did people with low B12 levels and normal folate levels. However, many of these studies were conducted in older people, a group more likely to have difficulty absorbing B12.

What medical conditions cause high folate levels?

There are several other medical conditions that may increase folic acid needs including anyone taking medications for epilepsy, Rheumatoid arthritis, lupus, psoriasis, asthma, and inflammatory bowel disease; anyone with kidney disease who is on dialysis; anyone with liver, sickle cell, or celiac diseases.

Why would my folate be high?

High levels of folate in the blood may mean that you eat a diet rich in folate or folic acid, take vitamins, or take folic acid pills. Consuming more folate than the body needs does not cause problems. High folate levels can also mean a vitamin B12 deficiency. Body cells need vitamin B12 to use folate.

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What symptom of vitamin B12 deficiency is masked by high folate intake?

The results of the first study suggest that during vitamin B12 deficiency, high serum folate levels exacerbate (rather than mask) anemia and also exacerbate cognitive symptoms.

What are the side effects of too much folate?

Although doses up to 5 mg daily have been safely used in some research, doses of folic acid greater than 1 mg daily might cause abdominal cramps, diarrhea, rash, sleep disorders, irritability, confusion, nausea, stomach upset, behavior changes, skin reactions, seizures, gas, excitability, and other side effects.

Should I be worried if my B12 is high?

Though daily high doses of B12 are unlikely to cause harm in most people, extremely high doses should be avoided unless prescribed by a healthcare professional. If you think you may be deficient in B12, speak with your doctor, who can recommend an appropriate treatment based on your level of deficiency.

What is considered a high folate level?

The reference range of the red blood cell (RBC) folate level also varies by age, as follows: Adults: 140-628 ng/mL or 317-1422 nmol/L. Children: Over 160 ng/mL or over 362 nmol/L.

How do you treat high folate levels?

A high folate intake can mask vitamin B-12 deficiency until its neurological effects become irreversible. This can typically be remedied by taking a supplement containing 100 percent of the daily value of both folic acid and vitamin B-12.

What is the normal range for folate in blood test?

Normal Results

The normal range is 2.7 to 17.0 nanograms per milliliter (ng/mL) or 6.12 to 38.52 nanomoles per liter (nmol/L). Normal value ranges may vary slightly among different labs.

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Why would B12 levels be high?

Usually, excess vitamin B12 is removed in the urine. Conditions that can increase B12 level include: Liver disease (such as cirrhosis or hepatitis) Myeloproliferative disorders (for example, polycythemia vera and chronic myelogenous leukemia)

What does high B12 mean in a blood test?

Elevated levels of serum cobalamin may be a sign of a serious, even life-threatening, disease. Hematologic disorders like chronic myelogeneous leukemia, promyelocytic leukemia, polycythemia vera and also the hypereosinophilic syndrome can result in elevated levels of cobalamin.

What folate does to the body?

Folic acid helps make healthy red blood cells, which carry oxygen around the body. If we do not have enough folic acid, the body can make abnormally large red blood cells that do not work properly. This causes folate deficiency anaemia, which can cause tiredness and other symptoms.

Is vitamin B12 the SAMe as folate?

Vitamin B12, also called cobalamin, is found in foods from animals, such as red meat, fish, poultry, milk, yogurt, and eggs. Folate (Vitamin B9) refers to a natural occurring form of the vitamin, whereas folic acid refers to the supplement added to foods and drinks.

How does folate and B12 work together?

Folate and B12 work together to produce S-adenosylmethionine (SAMe), a compound involved in immune function and mood. Vitamins B12, B6, and B9 work together to control blood levels of the amino acid homocysteine.

Does folic acid reduce B12?

Folic acid will correct the anaemia of vitamin B12 deficiency and so delay diagnosis but will not prevent progression to neurological damage. For this reason trials of folic acid supplements may involve simultaneous administration of vitamin B12.

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