FAQ: Deficiencies In Folate And Vitamin B12 Alter The Synthesis Of Which Of The Following?

What synthesis process is altered by deficiencies in folate and vitamin B12?

The pathophysiology of this group of anemia is ineffective erythropoiesis secondary to intramedullary apoptosis of hematopoietic cell precursors, which results from DNA synthesis abnormalities. Both vitamin B12 and folate deficiencies may cause defective DNA synthesis.

What causes B12 and folate deficiency?

Causes of a vitamin B12 or folate deficiency

pernicious anaemia – where your immune system attacks healthy cells in your stomach, preventing your body absorbing vitamin B12 from the food you eat; this is the most common cause of vitamin B12 deficiency in the UK.

What is a common deficiency syndrome of folate and vitamin B12?

Vitamin deficiency anemia is a lack of healthy red blood cells caused when you have lower than normal amounts of certain vitamins. Vitamins linked to vitamin deficiency anemia include folate, vitamin B-12 and vitamin C.

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How does vitamin B12 deficiency affect the body?

If you have vitamin B12 deficiency, you could become anemic. A mild deficiency may cause no symptoms. But if untreated, it may lead to symptoms such as: Weakness, tiredness, or lightheadedness.

Can a CBC detect vitamin B12 deficiency?

Macrocytic/megaloblastic anemia and large red blood cells are associated with a vitamin B12 or folate deficiency and are often initially detected during a routine CBC. In addition, abnormal physical characteristics of some of the cells are identified that are consistent with these deficiencies.

Is vitamin B12 stored in the liver?

Vitamin B12 is a water-soluble vitamin. Water-soluble vitamins dissolve in water. After the body uses these vitamins, leftover amounts leave the body through the urine. The body can store vitamin B12 for years in the liver.

Is folate and vitamin B12 the same thing?

Vitamin B12, also called cobalamin, is found in foods from animals, such as red meat, fish, poultry, milk, yogurt, and eggs. Folate (Vitamin B9) refers to a natural occurring form of the vitamin, whereas folic acid refers to the supplement added to foods and drinks.

What problems can a folate deficiency cause?

Folate deficiency can cause anemia. Anemia is a condition in which you have too few RBCs. Anemia can deprive your tissues of oxygen it needs because RBCs carry the oxygen.

The symptoms of anemia that occur due to folate deficiency include:

  • persistent fatigue.
  • weakness.
  • lethargy.
  • pale skin.
  • shortness of breath.
  • irritability.

Which is one of the first symptoms of folate deficiency?

Common symptoms of folate deficiency can include:

  • Tiredness, fatigue and lethargy.
  • Muscle weakness.
  • Neurological signs, such as a feeling of pins and needles, tingling, or burning, or peripheral neuropathy, i.e. a numbness in the extremities.
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What is the relationship between folate and vitamin B12 quizlet?

B12 is the cofactor for demethylating the folate we injest so we can use it for nucleic acid synthesis.

Can you take folic acid and vitamin B12 together?

No interactions were found between folic acid and Vitamin B12. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Is folic acid a B12?

Vitamin B12 deficiency produces both an anaemia identical to that of folate deficiency but also causes irreversible damage to the central and peripheral nervous systems. Folic acid will correct the anaemia of vitamin B12 deficiency and so delay diagnosis but will not prevent progression to neurological damage.

What are the neurological symptoms of B12 deficiency?

A lack of vitamin B12 can cause neurological problems, which affect your nervous system, such as:

  • vision problems.
  • memory loss.
  • pins and needles (paraesthesia)
  • loss of physical co-ordination (ataxia), which can affect your whole body and cause difficulty speaking or walking.

What medications should not be taken with B12?

Certain medications can decrease the absorption of vitamin B12, including: colchicine, metformin, extended-release potassium products, antibiotics (such as gentamicin, neomycin, tobramycin), anti-seizure medications (such as phenobarbital, phenytoin, primidone), medications to treat heartburn (such as H2 blockers

What vitamin deficiency can cause dizziness?

Low Vitamin B12 Levels Can Cause Dizziness

Vitamin B12 deficiency is easy to detect and treat, but is an often overlooked cause of dizziness,” he notes.

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